In a large bowl, combine ground beef, salt, pepper, garlic powder, onion powder, Worcestershire sauce, and ketchup. Mix gently until just combined. Do not overmix.

Divide mixture into 4 equal portions and shape into patties about ¾-inch thick.

Press a small indentation in the center of each patty with your thumb to help prevent puffing while cooking.

Heat a grill, skillet, or griddle over medium-high heat.

Cook patties for 4–5 minutes per side for medium doneness, or longer to your preferred temperature.

Add cheese during the last minute of cooking if desired.

Toast buns lightly and assemble burgers with favorite toppings.